Evaluation of Iron Supplementation Effects on Plasma Lipid Levels in Pregnant Women

Main Article Content

Safa F. Omer
Suaad Elnour
GadAllah Modawe

Abstract

Backgrounds: Iron supplementation is most widely used approach of controlling the global problem of iron deficiency anemia especially in pregnant anemic women. Anemia is one of the most frequent complications related to pregnancy. Normal physiological changes in pregnancy affect the hemoglobin (Hb), Epidemiological studies have shown high serum iron concentrations following abnormal levels of blood lipids are risk factors for coronary artery disease and myocardial infarction. Both iron deficiency anemia and dyslipidaemia are widely prevalent public health problems, especially in the Sudanese pregnant women.

Objectives: The aim of present study was to measure the serum level of lipids profile in anemic pregnant women compared to non anemic pregnant women.

Methodology and Study Population: The analytical case control study conducted in obstetrics and gynecology centre, Omdurman city, Khartoum state. One hundred subjects known with 50 pregnant anemic as case groups and 50 non anemic pregnant  women as control groups were enrolled in this study, with  match age and sex,  the age ranged between (20 to 40 years) and their mean (31.7±4.34). The serum lipid profile was analyzed using spectrophotometric method.

Results: The (mean±SD) of Hb, HDL, LDL, TG and TC in anemic pregnant women respectively were (68.15±9.35, 46.06±9.62, 114.14±36.86, 170.38±54.57. 197.16±46.83). While the (mean±SD) of Hb, HDL, LDL, TG and TC in non anemic pregnant women respectively were (79.76±7.22, 47.44±9.65, 140.00±40.76, 189.72±37.89, 224.38±45.09). The concentration of Hb was highly significantly decrease in anemic pregnant compare to non anemic pregnant women with p value (p=0.000). The level serum of LDL, TG and TC were significantly decrease in anemic pregnant compare to non anemic pregnant women with p value (p= 0.001, 0.042, 0.004) respectively.  The age of study population were no correlation with serum LDL(r= -0.155, p= 0.283), HDL(r= -0.019, p=0.898) and TC (r=0.68, p=0.640). And also their positive correlation between age and serum TG (r= 0.286, P=0.044).

Conclusion: The anemic pregnant women had a significantly decreased of Hb and serum LDL, TG and TC and also their positive correlation between age and serum TG.

Keywords:
Pregnant women, anemic women, serum lipid profile, Sudanese.

Article Details

How to Cite
Omer, S. F., Elnour, S., & Modawe, G. (2019). Evaluation of Iron Supplementation Effects on Plasma Lipid Levels in Pregnant Women. Journal of Advances in Medicine and Medical Research, 30(8), 1-7. https://doi.org/10.9734/jammr/2019/v30i830217
Section
Original Research Article

References

Boyd EM. Pattern of lipid parameters in healthy women during pregnancy. J. Clin. Invest. 1934;13:347–363.

Stock MJ, Metcalfe J. Maternal physiology during gestation. In: Knobil E, Neil JD. (eds): The physiology of reproduction. Raven press, New York. 1994;947–983.

de Valk B, Addicks MA, Gosriwatana I, Lu S, Hider RC, Marx JJ. Nontransferrin- bound iron is present in serum of hereditary haemochromatosis heterozy-gotes. Eur J Clin Invest. 2000;30:248-251.

Vaya A, Iborra J, Falco C, Moreno I, Bolufer P, Ferrando F, Perez ML, Justo Aznar. Rheological behaviour of red blood cells in beta and Deltabeta thalassemia minor. Clin Hemorheol Microcirc. 2003;28: 71-8.

Brizzi P, Tonolo G, Esposito F, et al. Lipoprotein metabolism during normal pregnancy. Am J Obstet Gynaecol. 1999; 181:430-434.

Kaaja R. Insulin resistance syndrome in preeclampsia. Sem Reprod Endocrinol. 1998;16:41-46.

Toescu V, Nuttall SL, Martin U, Kendall MJ, Dunne F. Oxidative stress and normal pregnancy. Clin Endocrinol (Oxford). 2002; 57:609-613.

Brittenham GM. Disorder of iron metabolism: Iron deficiency and iron overload, in Hematology: Basic principles and practice, Hoffman RE, Benz J, JR; SJ. Shattil et al. eds; Churchill Livingstone, Philadelphia. 2000;416.

Ravishanar S, Anil N, Muninarayana C, Prathima S, Sheela S. Prevalnce of anemia among pregnant women. Inter Journal of Med and Public Heath. 2016;5-3.

Malik G, Chandranai L, Ruwan F. Intermittent oral iron supplement during pregnancy. Ceylon Medical Journal. 2001; 46(4).

Festus O, Idonije O, Eseigbe M. Comparative study of lipid profile of normal pregnant women in the different trimesters. Arch. Appl. Sci. Res. 2011;3(3):528- 532.

Amit K, Abbas A, Sanjay M. Iron supplementation and lipid profiles in pregnant women. (IJSR). 2016;5(1).

Aziz R, Mahboob T. Pre-eclampsia and lipid profile. Pak J Med Sci. 2007;23:751-754.

Habbel RP, Eaton JW, Balasingam M, Steinberg MH. Spontaneous oxygen radical generation by sickle erythrocytes. J Clin Invest. 1982;70:1253-1259.

Aslan M, Thornley-Brown D, Freeman BA. Reactive species in sickle cell disease. Ann N Y Acad Sci. 2000;899:375-391.

Toescu V. Oxidative stress and normal pregnancy. Clinical Endocrinology (Oxford). 2002;57:609-613.

Choi JW. Changes in serum lipid concentrations during Iron depletion and after iron supplementation. Annals of Clinical & Laboratory Science. 2001;31: 151-156.

Tanzer F. Serum free carnitine and total triglyceride levels in children with iron deficiency anemia. International Journal for Vitamin and Nutrition Research. 2001;71: 66-69.