Journal of Advances in Medicine and Medical Research 2020-04-07T07:26:40+00:00 Journal of Advances in Medicine and Medical Research Open Journal Systems <p style="text-align: justify;"><strong>Journal of Advances in Medicine and Medical Research (ISSN:&nbsp;2456-8899)</strong> aims to publish research papers, reviews and short communications in the areas of medicine and medical research.&nbsp; JAMMR will not only publish traditional full research reports, including short communications, but also this journal will publish reports/articles on all stages of the research process like study protocols, pilot studies and pre-protocols. JAMMR is novelty attracting, open minded, peer-reviewed medical periodical, designed to serve as a perfectly new platform for both mainstream and new ground shaking works as long as they are technically correct and scientifically motivated.&nbsp;The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> Renal Oncocytoma: Report of Two Cases and Review of the Literature 2020-04-07T07:26:40+00:00 E. O. Ofori B. A. Bin Alhassan K. Akakpo E. G. Imbeah A. Asante-Asamani P. Maison G. A. Rahman <p><strong>Introduction:</strong> Renal oncocytomas are benign tumours arising from the intercalated cells of the collecting ducts and account for 3% to 7% of primary renal tumours. It was first described by Zippel in 1942. Oncocytomas are mostly asymptomatic and often discovered incidentally. They are often diagnosed postoperatively due to clinical and radiographic challenges in differentiating them from renal cell carcinoma.</p> <p><strong>Presentation of Case:</strong> The present study reports two cases of renal oncocytoma in a 61‑year‑old man who was asymptomatic and a 73‑year‑old woman who was symptomatic. Relevant clinical and imaging data on the two patients were reviewed. Both patients underwent nephrectomy via flank incisions.</p> <p><strong>Discussion:</strong> The typical morphologic features of oncocytoma were observed on histological examination of the excised kidney speci­mens. The postoperative course of each patient was uneventful and they were discharged 14 and 6-days post‑surgery, respec­tively. In addition, the present study reviews the literature regarding the clinical, radiological and pathological characteristics of renal oncocytoma.</p> <p><strong>Conclusion: </strong>Renal oncocytoma though is benign and has an excellent prognosis, the preoperative diagnostic challenges invariable warranted radical nephrectomy.</p> 2020-04-07T00:00:00+00:00 ##submission.copyrightStatement## Hepatotoxic Effect of Port Harcourt Eliozu Landfill Leachate in Wistar Rats 2020-04-06T12:44:58+00:00 I. I. Weleh O. A. Georgewill L. C. Barizoge D. V. Dapper <p>Studies have reported deleterious effect of landfill leachate and their surrounding water sources around the world. None has been reported on the Port Harcourt (Eliozu) landfill. This therefore necessitates this study that evaluated the hepatotoxic effects of Port Harcourt (Eliozu) landfill in wistar rats. 25 wistar rats were grouped into five of five rats each. Group 1 served as the control and received 1 ml of commercial non-carbonated bottled water; Group 2 served as negative control and received 1 ml of water obtained from borehole about 1 km from the landfill; while Groups 3, 4 and 5 received 1 ml of 10% of leachate concentration, 1 ml of 50% of leachate concentration and 1 ml of 100% of leachate concentration respectively once daily for 90 days. After the treatment period, the rats were sacrificed and 5 ml of blood was collected via cardiac puncture. The blood samples were prepared and used for the determination of serum concentrations of liver enzymes. The rats were also dissected and the liver harvested for histochemical analysis using the periodic acid Schiff stain. Result showed the serum concentrations liver enzymes significantly increased in the rats exposed to the leachate and water from a nearby borehole. Also histochemistry examination showed a marked distortion of the hepatic cells and cirrhotic change in the test groups compared to control. This study therefore concludes that exposure to Port Harcourt Eliozu landfill leachate (PELL) may cause significant hepatotoxicity in rats.</p> 2020-04-06T00:00:00+00:00 ##submission.copyrightStatement## Revisiting Puerperal Sepsis in Obsteric Referal Centres in Port Harcourt, Southern Nigeria 2020-04-06T12:59:01+00:00 Oranu Emmanuel Okwudili Owolabi Ayodeji Oluwaseun I. Nonye-Enyindah Esther <p><strong>Background: </strong>As the frontier of knowledge expands, surgical skills improve; and with the advent of increasingly potent antibiotics, it is expected that puerperal sepsis and its complications as captured in the literature of studies will be on the down turn. With this in mind, we decided to find out what is current as par risk factors and complications of puerperal sepsis in these obstetric referral centres in Port Harcourt.</p> <p><strong>Objective: </strong>To determine the risk factors and complications of puerperal sepsis at the University of Port Harcourt Teaching Hospital(UPTH), Port Harcourt and the River State University Teaching Hospital (RSUTH), Port Harcourt, Nigeria.</p> <p><strong>Methods: </strong>The case notes of these patients were retrieved from the medical records departments and relevant data extracted using a well-structured proforma.&nbsp; Data collected included the demographic characteristics, booking status, background immune suppression (HIV/AIDS or DM), labour characteristics, place and mode of delivery, fetal outcome, length of hospital stay. Morbidities like septicaemia, pelvic abscess, disseminated intravascular coagulopathy among others; and the presence of mortality was also noted. The data was analyzed using SPSS version 23.0. Statistical analysis of data was done by Chi-square test. A p-value less than 0.05 was considered significant. The result is presented in tables of frequencies and percentages.</p> <p><strong>Results: </strong>The prevalence of puerperal sepsis was 1.7%. Risk factors were low parity, unbooked status (84.35%) and wound infection (29.9%), among other intrauterine foetal death (22.8%), obstructed labour (14.2%) and perineal tear (11.0%). The main complications of puerperal sepsis noticed were prolonged hospital stay (58.3%) and septicaemia (13.4%); pelvic abscess (10.2%) and intestinal obstruction (4.7%) while (1)3.1% ended in mortality.</p> <p><strong>Conclusion: </strong>Complications of puerperal sepsis were still high in these centres. Worrisomely, a huge number of these patients were unbooked.</p> 2020-04-06T00:00:00+00:00 ##submission.copyrightStatement##