Antidepressant and Antiamnesic Potential of Foeniculum vulgare

Main Article Content

Afshan Abbas
Rahila Ikram
Faiza Hasan
Abeer Adil
Uzair Nisar
Qurat ul Ain


Aim: To evaluate the antiamnesic and antidepressant effect of Foeniculum vulgare whole crushed seeds.

Study Design: Laboratory based randomized control study.

Place and Duration of Study: Department of Pharmacology, University of Karachi between January 2018 to August 2018. 

Methodology: Thirty swiss albino mice and wistar rats were divided equally in three groups. Control group was fed on standard rodent diet, group 2 was fed on 2% Foeniculum vulgare diet and group 3 was given 4% Foeniculum vulgare diet. Antidepressant activity was assessed using forced swimming test. Memory enhancement effect was evaluated by stationary rod test, passive avoidance test and water maze test.

Results: Increased duration of struggling time was noted in both group 2 and group 3 as compared to control in forced swimming test. Decrease in time to reach platform in both water maze and stationary rod test was recorded in both the study group (group 2 & 3). Increase in step through latency was also seen in group 2 and group 3 as compared to control group.

Conclusion: The results showed the memory enhancing and antidepressant actions of Foeniculum.

Antiamnesic, antidepressant, Foeniculum vulgare, mice, rats.

Article Details

How to Cite
Abbas, A., Ikram, R., Hasan, F., Adil, A., Nisar, U., & Ain, Q. ul. (2020). Antidepressant and Antiamnesic Potential of Foeniculum vulgare. Journal of Advances in Medicine and Medical Research, 32(1), 131-138.
Original Research Article


Najam R, Anser H. Behavioral and memory boosting effects of intellan and cyanocobalamin in mice. Journal of Pharmacy and Nutrition Sciences. 2011; 1(1):28-33.

Nasrullah M, Haque A, Yasmin Z, Uddin MA, Biswas K, Islam MS. Phytochemical screening, antioxidant and anticholinesterase effects of Alangium salvifolium (LF) Wang root extracts. Journal of Medicinal Plants Research. 2015;9(42):1060-9.

Skriver K, Roig M, Lundbye-Jensen J, Pingel J, Helge JW, Kiens B, Nielsen JB. Acute exercise improves motor memory: Exploring potential biomarkers. Neurobiology of Learning and Memory. 2014;116:46-58.

Kempadoo KA, Mosharov EV, Choi SJ, Sulzer D, Kandel ER. Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory. Proceedings of the National Academy of Sciences. 2016;113(51): 14835-40.

Markowitz DA, Curtis CE, Pesaran B. Multiple component networks support working memory in prefrontal cortex. Proceedings of the National Academy of Sciences. 2015;112(35):11084-9.

Driesen NR, McCarthy G, Bhagwagar Z, Bloch MH, Calhoun VD, D'souza DC, Gueorguieva R, He G, Leung HC, Ramani R, Anticevic A. The impact of NMDA receptor blockade on human working memory-related prefrontal function and connectivity. Neuropsychopharmacology. 2013;38(13):2613-22.

Valentim JrSJ, Gontijo AV, Peres MD, de Melo Rodrigues LC, Nakamura-Palacios EM. D1 dopamine and NMDA receptors interactions in the medial prefrontal cortex: Modulation of spatial working memory in rats. Behavioural Brain Research. 2009; 204(1):124-8.

Lépine JP, Briley M. The increasing burden of depression. Neuropsychiatric Disease and Treatment. 2011;7(Suppl 1):3.

Perveen T, Emad S, Ahmad S, Batool Z, Yousuf S, Sheikh S, Qadeer S, Haider S. Fennel oil treatment mimics the anti-depressive and anxiolytic effects of fluoxetine without altering the serum cholesterol levels in rats. Pakistan Journal of Zoology. 2017;49(6).

Kessler RC, Adler LA, Berglund P, Green JG, McLaughlin KA, Fayyad J, Russo LJ, Sampson NA, Shahly V, Zaslavsky AM. The effects of temporally secondary co-morbid mental disorders on the associations of DSM-IV ADHD with adverse outcomes in the US National Comorbidity Survey Replication Adolescent Supplement (NCS-A). Psychological Medicine. 2014;44(8):1779-92.

Dhingra S, Parle M. Herbal remedies and nutritional supplements in the treatment of depression: A review. Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology. 2012;22(3):286-92.

Badhe SR, Badhe RV, Ghaisas MM, Chopade VV, Deshpande AD. Evaluations of antidepressant activity of Anacyclus pyrethrum root extract. International Journal of Green Pharmacy (IJGP). 2010; 4(2).

Jamwal NS, Kumar S, Rana AC. Phytochemical and pharmacological review on Foeniculum vulgare. Pharma Science Monitor. 2013;4(3).

Kooti W, Moradi MT, Ali-Akbari S, Sharafi-Ahvazi N, Asadi-Samani M, Ashtary-Larky D. Therapeutic and pharmacological potential of Foeniculum vulgare Mill: A review. Journal of Herb Med Pharmacology. 2014;4.

Mansouri E, Kooti W, Bazvand M, Boroon MG, Amirzargar A, Afrisham R, Afzalzadeh MR, Ashtary-Larky D, Jalali N. The effect of hydro-alcoholic extract of Foeniculum vulgare Mill on leukocytes and hematological tests in male rats. Jundishapur Journal of Natural Pharmaceutical Products. 2015;10(1).

Salama ZA, El Baz FK, Gaafar AA, Zaki MF. Antioxidant activities of phenolics, flavonoids and vitamin C in two cultivars of fennel (Foeniculum vulgare Mill.) in responses to organic and bio-organic fertilizers. Journal of the Saudi Society of Agricultural Sciences. 2015;14(1):91-9.

Saxena S, Agarwal D, John S, Dubey P, Lal G. Analysis of fennel (Foeniculum vulgare) essential oil extracted from green leaves, seeds and dry straw. International J. Seed Spices. 2018;8(1):60-4.

Pacifico S, Galasso S, Piccolella S, Kretschmer N, Pan SP, Nocera P, Lettieri A, Bauer R, Monaco P. Winter wild fennel leaves as a source of anti-inflammatory and antioxidant polyphenols. Arabian Journal of Chemistry. 2018;11(4):513-24.

Fatima SA, Baig SG, Hasan MM, Ahmed S. Analgesic and anti-inflammatory activities of fixed oil of Macrotyloma uniflorum (Lam.) Verdc. in mice and rats. Pak. J. Pharm. Sci. 2018;31(2):581-5.

Abbas A, Ikram R, Khan SS, Ahmed S, Osama M. The Fennel, Foeniculum vulgare incorporated diet shows anxiolytic potential: A pre-clinical study. Pakistan Journal of Pharmaceutical Sciences. 2019; 32(4 (Supplementary)):1813-9.

Adel A, Ikram R, Wasi N. Salvia hispanica (White chia): A new window for its antidepressant and memory boosting activity. Pakistan Journal of Pharmaceutical Sciences. 2019;32(3): 1005-9.

Illouz T, Madar R, Louzon Y, Griffioen KJ, Okun E. Unraveling cognitive traits using the Morris water maze unbiased strategy classification (MUST-C) algorithm. Brain, Behavior, and Immunity. 2016;52:132-44.

Barkur RR, Bairy LK. Evaluation of passive avoidance learning and spatial memory in rats exposed to low levels of lead during specific periods of early brain development. International Journal of Occupational Medicine and Environmental Health. 2015;28(3):533.

Yang C, Hu YM, Zhou ZQ, Zhang GF, Yang JJ. Acute administration of ketamine in rats increases hippocampal BDNF and mTOR levels during forced swimming test. Upsala Journal of Medical Sciences. 2013; 118(1):3-8.

Nabi NU. Natural remedies for improving learning and memory-review. International Journal of Pharmaceutical and Phytopharmacological Research. 2014; 3(2).

Brühlmann C, Ooms F, Carrupt PA, Testa B, Catto M, Leonetti F, Altomare C, Carotti A. Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase. Journal of Medicinal Chemistry. 2001;44(19):3195-8.

Joshi H, Parle M. Cholinergic basis of memory-strengthening effect of Foeniculum vulgare Linn. Journal of Medicinal Food. 2006;9(3):413-7.

Koppula S, Kumar H. Foeniculum vulgare Mill (Umbelliferae) attenuates stress and improves memory in wister rats. Tropical Journal of Pharmaceutical Research. 2013;12(4):553-8.

Ali B, Al-Wabel NA, Shams S, Ahamad A, Khan SA, Anwar F. Essential oils used in aromatherapy: A systemic review. Asian Pacific Journal of Tropical Biomedicine. 2015;5(8):601-11.

Glory Josephine I, Elizabeth AA, Punnagai K, Muthiah NS. Comparative study of Vetiveria zizanioides and Foeniculum vulgare extracts on behavioral despair of Wistar albino rats. Journal of Chemical and Pharmaceutical Research. 2015;7(8):729-34.

Jamwal NS, Kumar S, Rana AC. Antidepressant Activity of Methanolic Extract of Foeniculum Vulgare (Fennel) fruits in experimental animal models. Journal of Applied Pharmaceutical Science. 2013;3(09):065-070.

Miller AH, Maletic V, Raison CL. Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression. Biological Psychiatry. 2009;65(9):732-41.

Xu Y, Wang C, J Klabnik J, M O'Donnell J. Novel therapeutic targets in depression and anxiety: Antioxidants as a candidate treatment. Current Neuropharmacology. 2014;12(2):108-19.

Berk M, Kapczinski F, Andreazza AC, Dean OM, Giorlando F, Maes M, Yücel M, Gama CS, Dodd S, Dean B, Magalhães PV. Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors. Neuroscience & Biobehavioral Reviews. 2011;35(3):804-17.

Aboul-Fotouh S. Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats. Pharmacology Biochemistry and Behavior. 2013;104:105-12.

Jindal A, Mahesh R, Bhatt S. Etazolate, a phosphodiesterase 4 inhibitor reverses chronic unpredictable mild stress-induced depression-like behavior and brain oxidative damage. Pharmacology Biochemistry and Behavior. 2013;105:63-70.

Aggarwal BB, Kunnumakkara AB, Harikumar KB, Tharakan ST, Sung B, Anand P. Potential of spice-derived phytochemicals for cancer prevention. Planta Medica. 2008;74(13):1560-9.

Thakur P, Rana AC. Anxiolytic potential of medicinal plants. International Journal of Nutrition, Pharmacology, Neurological Diseases. 2013;3(4):325.

Roby MH, Sarhan MA, Selim KA, Khalel KI. Antioxidant and antimicrobial activities of essential oil and extracts of fennel (Foeniculum vulgare L.) and chamomile (Matricaria chamomilla L.). Industrial Crops and Products. 2013;44:437-45.

Saaby L, Rasmussen HB, Jäger AK. MAO-A inhibitory activity of quercetin from Calluna vulgaris (L.) Hull. Journal of Ethnopharmacology. 2009;121(1):178-81.

Lee SH, Paz-Filho G, Mastronardi C, Licinio J, Wong ML. Is increased antidepressant exposure a contributory factor to the obesity pandemic?. Translational Psychiatry. 2016;6(3):e759.

Raeder MB, Bjelland I, Emil SV, Steen VM. Obesity, dyslipidemia and diabetes with selective serotonin reuptake inhibitors: The Hordaland Health Study. The Journal of Clinical Psychiatry. 2006;67(12):1974-82.

Shahat AA, Ibrahim AY, Hendawy SF, Omer EA, Hammouda FM, Abdel-Rahman FH, Saleh MA. Chemical composition, antimicrobial and antioxidant activities of essential oils from organically cultivated fennel cultivars. Molecules. 2011;16(2): 1366-77.

Kulisic‐Bilusic T, Blažević I, Dejanović B, Miloš M, Pifat G. Evaluation of the antioxidant activity of essential oils from caper (Capparis spinosa) and sea fennel (Crithmum maritimum) by different methods. Journal of Food Biochemistry. 2010;34:286-302.

Choi EM, Hwang JK. Anti-inflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare. Fitoterapia. 2004;75(6):557-65.