Effect of Antiasthma Medication on Blood Eosinophil Count and Serum Immunoglobulin E Levels: A Randomized Controlled Study

Main Article Content

Wasim A. Wani
Sheeraz A. Dar
Khalid M. Kawosa
Mudasir Nazir
Ikhlas Ahmad
Asif Ahmed

Abstract

Background: Asthma is a chronic inflammatory condition of lung airways resulting in episodic airflow obstruction.

Aims: The main objective of this study is to find the effect of antiasthma medication on serum IgE levels and blood eosinophil count.

Study Design: This randomized controlled trial study was performed in children aged 6-15 years of age, with clinically stable and moderate persistent asthma.

Results: The findings of this study indicate both group (Budesonide/formoterol group and budesonide group) patients experienced a significant decrease in serum IgE levels and blood eosinophil counts over the study period. However, the difference in two groups was not statistically significant.

Conclusions: Inhaled steroids are effective in controlling systemic inflammation in asthma as evidenced by a decrease in IgE levels and eosinophil counts. However addition of LABA doesn’t have any additive effect.

Keywords:
Asthma, budesonide, eosinophil, IgE levels, inhaled steroids, LABA

Article Details

How to Cite
Wani, W. A., A. Dar, S., Kawosa, K. M., Nazir, M., Ahmad, I., & Ahmed, A. (2020). Effect of Antiasthma Medication on Blood Eosinophil Count and Serum Immunoglobulin E Levels: A Randomized Controlled Study. Journal of Advances in Medicine and Medical Research, 32(6), 33-39. https://doi.org/10.9734/jammr/2020/v32i630430
Section
Original Research Article

References

Asthma WSE. Defining of the persistent adult phenotypes. Lancet. 2006;368:804–13.

Lotvall J, Akdis CA, Bacharier LB, Bjermer L, Casale TB, Custovic A, et al. Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome. J Allergy ClinImmunol. 2011;127:355–6.

Ricci M, Rossi O, Bertoni M, Matucci A. The importance of Th2-like cells in the pathogenesis of airway allergic inflammation. ClinExp Allergy. 1993;23: 360–9.

Woodfolk JA. T-cell responses to allergens. J Allergy ClinImmunol. 2007; 119:280–94.

Romagnani S. Immunologic influences on allergy and the TH1/TH2 balance. J Allergy ClinImmunol. 2004;113:395–400.

Matucci A, Vultaggio A, Maggi E, Kasujee I. Is IgE or eosinophils the key player in allergic asthma pathogenesis? Are we asking the right question?. Respiratory Research. 2018;19(1): 113.

Maurer D, Fiebiger S, Ebner C, Reininger B, Fischer GF, Wichlas S, et al. Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha-and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation. J Immunol. 1996; 157:607–16.

Redhu NS, Gounni AS. The high affinity IgE receptor (FcεRI) expression and function in airway smooth muscle. Pulm Pharmacol Ther. 2013;26:86–94.

Sihra BS, Kon OM, Grant JA, Kay AB. Expression of high-affinity IgE receptors (Fc epsilon RI) on peripheral blood basophils, monocytes, and eosinophils in atopic and nonatopic subjects: Relationship to total serum IgE concentrations. J Allergy ClinImmunol. 1997;99:699–706.

Kraft S, Kinet JP. New developments in FcεRI regulation, function and inhibition. Nat Rev Immunol. 2007;7:365–78.

Gaurav R, Agrawal DK. Clinical view on the importance of dendritic cells in asthma. Expert Rev ClinImmunol. 2013;9:899–919.

Froidure A, Shen C, Pilette C. Dendritic cells revisited in human allergic rhinitis and asthma. Allergy. 2016;71:137–48.

Schroeder JT, Bieneman AP, Chichester KL, Hamilton RG, Xiao H, Saini S, et al. Decreases in human dendritic cell-dependent T(H)2-like responses after acute in vivo IgE neutralization. J Allergy ClinImmunol. 2010;125:896–901.

Khan SH, Grayson MH. Cross-linking IgE augments human conventional dendritic cell production of CC chemokine ligand 28. J Allergy ClinImmunol. 2010;125:265–7.

Lynch P, Mazzone SB, Rogers MJ, Arikkatt JJ, Loh Z, Pritchard AL, et al. The plasmacytoid dendritic cell: At the cross-roads in asthma. EurRespir J. 2014;43:264–75.

Kelly JT, Busse WW. Host immune responses to rhinovirus: mechanisms in asthma. J Allergy ClinImmunol. 2008;122: 671–84.

Busse WW, Morgan WJ, Gergen PJ, Mitchell HE, Gern JE, Liu AH, et al. Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. New Engl J Med. 2011;364:1005–15.

Bousquet J, Chanez P, Lacoste JY, Barneon G, Ghavanian N, Enander I, et al. Eosinophilic inflammation in asthma. N Engl J Med. 1990;323:1033–9.

Garcia G, Taille C, Laveneziana P, Bourdin A, Chanez P, Humbert M. Anti-interleukin-5 therapy in severe asthma. EurRespir Rev. 2013;22:251–7.

Price DB, Rigazio A, Campbell JD, Bleecker ER, Corrigan CJ, Thomas M, et al. Blood eosinophil count and prospective annual asthma disease burden: A UK cohort study. Lancet Respir Med. 2015;3:849–58.

Kita H. Eosinophils: Multifaceted biologic properties and roles in health and disease. Immunol Rev. 2011;242:161–77.

Nagata K, Hirai H, Tanaka K, Ogawa K, Aso T, Sugamura K, et al. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell- derived factor(s). FEBS Lett. 1999;459: 195–9.

Jousilahti P, Salomaa V, Hakala K, Rasi V, Vahtera E, Palosuo T. The association of sensitive systemic inflammation markers with bronchial asthma. Ann Allergy Asthma Immunol. 2002; 89:381-5.

Kerrebijin KF, Von Essen-Zandvliet EMM, Neijens HJ. Effect of long term treatment with an inhaled corticosteroid and beta agonists on bronchial responsiveness in asthmatic children. J Allergy ClinImmunol. 1987;79:653-9.

Kamaran O, Arli O, Uzuner N, Islekel H, Babayigit A, Olmez D, et al. The effectiveness of asthma therapy alternatives and evaluating the effectivity of asthma therapy by interleukin 13 and interferon gamma levels in children. Allergy Asthma Proc. 2007;28(2):204-9.