Diagnostic Accuracy of Cartilage Oligomeric Matrix Protein (COMP), for Cartilage Damage in Rheumatoid Arthritis
Journal of Advances in Medicine and Medical Research,
Background: Cartilage oligomeric matrix protein (COMP), is an extracellular matrix (ECM) non-collagenous glycoprotein that is mainly localized within the cartilage, and also be found in tendon and synovium.Recent studies in west and Asia Pacific region has shown that COMP, is a prognostic marker in Rheumatoid arthritis(RA).
Objective: To correlate serum COMP levels with disease severity and cartilage destruction in rheumatoid arthritis.
Methods: The study was conducted in Department of Pathology and Rheumatology, Ziauddin University Hospital, Karachi from June 2018 to May 2019. Patients were recruited as per American College of Rheumatology (ACR) 2010 classification criteria. The study population consists of 88 healthy subjects and 88 RA patients. Sandwich ELISA technique was used to assess serum COMP level. Other inflammatory markers such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) antibodies like rheumatoid factor, and anti-cyclic citrullinated protein (anti-CCP) were also assessed. Results were analyzed using SPSS-20 and P-value ≤0.05 was considered as significant.
Results: Serum COMP levels were significantly higher in RA patients 51.35 ng/ml than controls 21.454 ng/ml with significant p value=<0.0001. There was strong positive correlation between COMP level and disease severity in RA patients with moderate as well as high disease activity score (DAS) with significant p value. Serum COMP showed 96% sensitivity and 83% specificity at level of 27.01 ng/ml for diagnosis of RA.
Conclusions: COMP has significant positive correlation with severity of RA. Serum COMP can be utilized as a biomarker to quantify cartilage destruction in RA patients.
- Diagnostic accuracy
- Cartilage Oligomeric Matrix Protein (COMP)
- cartilage damage
- rheumatoid arthritis.
How to Cite
Riise T, Jacobsen BK, Gran J. Incidence and prevalence of rheumatoid arthritis in the county of Troms, northern Norway. The Journal of Rheumatology. 2000;27(6): 1386.
Gabriel SE. The epidemiology of rheumatoid arthritis. Rheumatic Disease Clinics of North America. 2001;27(2):269-81.
Carmona L, Villaverde V, Hernández‐ García C, Ballina J, Gabriel R, Laffon A. The prevalence of rheumatoid arthritis in the general population of Spain. Rheumatology. 2002;41(1):88-95.
Rudan I, Sidhu S, Papana A, Meng SJ, Xin–Wei Y, Wang W, et al. Prevalence of rheumatoid arthritis in low–and middle–income countries: A systematic review and analysis. Journal of Global Health. 2015; 5(1).
Alam SM, Kidwai AA, Jafri SR, Qureshi BM, Sami A, Qureshi HH, et al. Epidemiology of rheumatoid arthritis in a tertiary care unit, Karachi, Pakistan. JPMA-Journal of the Pakistan Medical Association. 2011;61(2):123.
Hassan G, Aboelnour E, Ibrahiem O, Mohammed EF. Novel molecular diagnostic marker in the evaluation of cartilage destruction in patients with rheumatoid arthritis. Journal of Current Medical Research and Practice. 2016; 1(3):72.
Mok CC, Cha HS, Hidayat R, Nguyen LTN, Perez EC, Ramachandran R, et al. The importance of assessment and management of morning stiffness in Asian patients with rheumatoid arthritis: Recommendations from an expert panel. International Journal of Rheumatic Diseases. 2016;19(1):30-7.
Sokka T, Toloza S, Cutolo M, Kautiainen H, Makinen H, Gogus F, et al. Women, men, and rheumatoid arthritis: Analyses of disease activity, disease characteristics, and treatments in the QUEST-RA study. Arthritis Research & Therapy. 2009;11(1): R7.
Mølbæk K, Hørslev‐Petersen K, Primdahl J. Diagnostic delay in rheumatoid arthritis: A qualitative study of symptom interpretation before the first visit to the doctor. Musculoskeletal Care. 2016;14(1): 26-36.
Mocelin V, Nisihara RM, Utiyama SR, Kotze LM, Ramos Jr O, Messias-Reason I. Anti-CCP Antibodies and rheumatological findings in brazilian patients with crohn's disease. Digestion. 2015;91(4):303-6.
Vignesh APP, Srinivasan R. Ocular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies. Clinical Ophthalmology (Auckland, NZ). 2015;9:393.
Andersson ML, Svensson B, Petersson IF, Hafström I, Albertsson K, Forslind K, et al. Early increase in serum-COMP is associated with joint damage progression over the first five years in patients with rheumatoid arthritis. BMC Musculoskeletal Disorders. 2013;14(1):229.
Tseng S, Reddi AH, Di Cesare PE. Cartilage oligomeric matrix protein (COMP): A biomarker of arthritis. Biomarker Insights. 2009;4:BMI, S645.
Sakthiswary R, Rajalingam S, Hussein H, Sridharan R, Asrul AW. Cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis and its correlation with sonographic knee cartilage thickness and disease activity. Clinical Rheumatology. 2017;36(12):2683-8.
Skoumal M, Kolarz G, Klingler A. Serum levels of cartilage oligomeric matrix protein A predicting factor and a valuable parameter for disease management in rheumatoid arthritis. Scandinavian Journal of Rheumatology. 2003;32(3):156-61.
Prevoo M, Van'T Hof MA, Kuper H, Van Leeuwen M, Van De Putte L, Van Riel P. Modified disease activity scores that include twenty‐eight‐joint counts development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology. 1995; 38(1):44-8.
Van Der Heijde D, Van Der Helm-Van AH, Aletaha D, Bingham CO, Burmester GR, Dougados M, et al. EULAR definition of erosive disease in light of the 2010 ACR/EULAR rheumatoid arthritis classification criteria. Annals of the Rheumatic Diseases. 2013;72(4):479-81.
Salaffi F, Carotti M, Carlo M. Conventional radiography in rheumatoid arthritis: New scientific insights and practical application. Int J Clin Exp Med. 2016;9(9):17012-27.
Christensen AF, Lindegaard H, Hørslev-Petersen K, Hetland ML, Ejbjerg B, Stengaard-Pedersen K, et al. Cartilage oligomeric matrix protein associates differentially with erosions and synovitis and has a different temporal course in cyclic citrullinated peptide antibody (anti-CCP)-positive versus anti-CCP-negative early rheumatoid arthritis. The Journal of Rheumatology. 2011;38(8): 1563-8.
Robinson WH, Lindstrom TM, Cheung RK, Sokolove J. Mechanistic biomarkers for clinical decision making in rheumatic diseases. Nature Reviews Rheumatology. 2013;9(5):267.
Algergawy SA, Abd El-Sabour M, Osman AS, Emam SM, Elham N. Early diagnostic and prognostic values of anti-cyclic citrullinated peptide antibody and cartilage oligomeric matrix protein in rheumatoid arthritis. Egypt J Immunol. 2013;20(2):11-20.
El Defrawy A, Gheita T, Raslan H, El Ansary M, El Awar A. Serum and synovial cartilage oligomeric matrix protein levels in early and established rheumatoid arthritis. Zeitschrift für Rheumatologie. 2016;75(9): 917-23.
Söderlin M, Kastbom A, Kautiainen H, Leirisalo‐Repo M, Strandberg G, Skogh T. Antibodies against cyclic citrullinated peptide (CCP) and levels of cartilage oligomeric matrix protein (COMP) in very early arthritis: Relation to diagnosis and disease activity. Scandinavian Journal of Rheumatology. 2004;33(3):185-8.
Krabbe S, Bolce R, Brahe C, Døhn U, Ejbjerg B, Hetland M, et al. Investigation of a multi-biomarker disease activity score in rheumatoid arthritis by comparison with magnetic resonance imaging, computed tomography, ultrasonography, and radiography parameters of inflammation and damage. Scandinavian Journal of Rheumatology. 2017;46(5):353-8.
Acharya C, Yik JH, Kishore A, Van Dinh V, Di Cesare PE, Haudenschild DR. Cartilage oligomeric matrix protein and its binding partners in the cartilage extracellular matrix: Interaction, regulation and role in chondrogenesis. Matrix Biology. 2014;37: 102-11.
Wisłowska M, Jabłońska B. Serum cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis and knee osteoarthritis. Clinical Rheumatology. 2005;24(3):278-84.
Algergawy S, Abd ME-S, Osman A, Emam S, Elham N. Early diagnostic and prognostic values of anti-cyclic citrullinated peptide antibody and cartilage oligomeric matrix protein in rheumatoid arthritis. The Egyptian Journal of Immunology. 2013; 20(2):11-20.
Abstract View: 248 times
PDF Download: 142 times