Platelet Indices before Vaginal Delivery in Healthy Teenage Pregnant Women Compared to Healthy Adult Pregnant Women
Journal of Advances in Medicine and Medical Research,
Aims: This work aimed to study whether there are any differences in platelet indices of the teenagers compared to adult pregnant women, differences that could be used for the benefit of the patients.
Study Design: Prospective study.
Place and Duration of Study: This study included all consecutive patients admitted for delivery between July 2019 and December 2019 in the Elena Doamna Obstetrics and Gynecology University Hospital, Iasi, Romania, who met the inclusion criteria.
Methodology: There were 167 patients (ranged between 14-46 years old). Complete blood count just before vaginal delivery was analyzed.
Results: A statistical difference (P=0.043) was found between plateletcrit values of healthy adolescents compared with healthy adult pregnant patients. No statistical difference was found between plateletcrit values in the 4 consecutive age groups. No pregnant patient had abnormal plateletcrit value. The neutrophil-to-lymphocyte ratios were significantly higher (P=0.024) in adolescents versus the over 40 age group; moreover, the teenage median values were slightly over the normal limits. The NLR values were significantly higher (P=0.013) in adolescent patients versus adult pregnant patients.
Conclusion: Even if plateletcrit or NLR values in teenage pregnant patients may be slightly higher than in adults, this was normal to happen in healthy patients, and required no therapeutic measures.
- Platelet indices
- vaginal delivery
How to Cite
Sedgh G, Finer L, Bankole A, Eilers M, Singh S. Adolescent pregnancy, birth, and abortion rates across countries: levels and recent trends. J Adolesc Health. 2015;56(2):223-30.
Darroch JE, Singh S, Frost JJ. Differences in teenage pregnancy rates among five developed countries: the roles of sexual activity and contraceptive use. Fam Plann Perspect. 2001;33(6):244-50,281.
Socolov DG, Iorga M, Carauleanu A et al. Pregnancy during adolescence and associated risks: An 8-year hospital-based cohort study (2007-2014) in Romania, the country with the highest rate of teenage pregnancy in Europe. Biomed Res Int. 2017;9205016.
DOI:10.1155/2017/9205016. Epub 2017 Jan 4.
Kawakita T, Wilson K, Grantz KL et al. Adverse maternal and neonatal outcomes in adolescent pregnancy. J Pediatr Adolesc Gynecol. 2016;(2):130-6.
DOI:10.1016/j.jpag.2015.08.006. Epub 2015 Aug 29.
Ganchimeg T, Ota E, Morisaki N et al. Pregnancy and childbirth outcomes among adolescent mothers: a World Health Organization multicountry study. BJOG. 2014;121 Suppl 1;40-8.
Suciu LM, Pasc AL, Cucerea M, Bell E. Teenage pregnancies: Risk factors and associated neonatal outcomes in an Eastern-European academic perinatal care center. Am J Perinatol. 2016;33(4):409-14.
DOI: 10.1055/s-0035-1565917. Epub 2015 Oct 20.
Jolly MC, Sebire N, Harris J, Robinson S, Regan L. Obstetric risks of pregnancy in women less than 18 years old. Obstet Gynecol. 2000;96(6):962-6.
Dimitriu M, Antoniu Ionescu C, Matei A et al. The problems associated with adolescent pregnancy in Romania: A cross-sectional study. J Eval Clin Pract. 2019;25(1):117-124.
DOI:10.1111/jep.13036. Epub 2018 Oct 17.
Moser G, Guettler J, Forstner D, Gauster M. Maternal Platelets-Friend or Foe of the Human Placenta? Int J Mol Sci. 2019;11;20(22):5639.
Oğlak SC, Aydin MF. Are neutrophil to lymphocyte ratio and platelet to lymphocyte ratio clinically useful for the prediction of early pregnancy loss? Ginekol Pol. 2020;91(9):524-527.
Swanepoel A, Pretorius E. Ultra structural analysis of platelets during three phases of pregnancy: A qualitative and quantitative investigation. Hematology. 2015;20(1):39-47.
DOI:10.1179/1607845413Y.0000000150 Epub 2014 Jan 20.
Szklanna P, Parsons M, Wynne K et al. The platelet realasate is altered in human pregnancy. Proteomics Clin Appl. 2019;13(3):e1800162.
DOI:10.1002/prca.201800162. Epub 2018 Oct 29.
Tian J, Cheng LHH, Ciu X, Lei XX, Tang JB, Cheng B. Investigating the effect of age on platelet ultrastructure using transmission electron microscopy. Int Wound J. 2019;16(6):1457-1463.
DOI:10.1111/iwj.13214. Epub 2019 Sep 5.
Cowman J, Dunne E, Oglesby I, et al. Age-related changes in platelet function are more profound in women than in men. Sci Rep. 2015;16;5:12235.
Vasqez-Santiago M, Ziyatdinov A, Pujol-Moix N, et al. Age and gender effects on 15 platelet phenotypes in a Spanish population. Comput Biol Med. 2016;1(69):226-33.
DOI: 10.1016/j.compbiomed.2015.12.023 Epb 2016 Jan 1.
Covali R, Socolov D, Socolov R. Coagulation tests and blood glucose before vaginal delivery in healthy teenage pregnant women compared to healthy adult pregnant women. Medicine (Baltimore). 2019;98(5):e14360.
Reese JA, Peck JD, McIntosh JJ, Vesely SK, George JN. Platelet counts in women with normal pregnancies: A systematic review. Am J Hematol. 2017;92(11):1224-1232.
DOI: 10.1002/ajh.24829. Epub 2017 Aug 17
Li A, Yang S, Zhang J, Qiao R. Establishment of reference intervals for complete blood count parameters during normal pregnancy in Beijing. J Clin Lab Anal. 2017;31(6).
DOI: 10.1002/jcla.22150. Epub 2017 Jan 20
Alemu A, Abebe M, Terefe B, et al. Hematological indices of pregnant women at the University of Gondar Referral Hospital, Northwest Ethiopia: A comparative cross-sectional study. Clin Lab. 2019;65(8).
Bakrim S, Motiaa Y, Oarour A, Masrar A. Hematological parameters of the blood count in a healthy population of pregnant women in the Northwest of Morocco (Tetouan-M’diq-Fnideq provinces). Pan Afr Med J. 2018;29:205.
DOI: 10.11604/pamj.2018.29.205.13043. eCollection 2018.
Reese JA, Peck JD, Deschamps DR, et al. Platelet counts during pregnancy. N Engl J Med. 2018;379(1):32-43.
American college of obstetricians and gynecologists’ committee of practice bulletins – Obstetrics. Practice Bulletin No. 166: Thrombocytopenia in pregnancy. Obstet Gynecol. 2016;(3):e43-53.
AlSheeha MA, Alaboudi RS, AlGhasam MA, Iqbal J, Adam I. Platelet count and platelet indices inn women with preeclampsia. Vasc Health Risk Manag. 2016;12:477-480.eCollection 2016.
Mayer-Pickel K, Stern C, Eberhard K, Lang U, Obermayer-Pietsch B, Cervar-Zivkovic M. Comparison of mean platelet volume (MPV) and sFlt-1/PIGF ratio as predictive markers for preeclampsia. J Matern Fetal Neonatal Med. 2019;9:1-8.
DOI: 10.1080/14767058.2019.1638356. [Epub ahead of print].
Tesfay F, Negash M, alemu J, et al. Role of platelet parameters in early detection and prediction of severity of preeclampsia: A comparative cross-sectional study at Ayder comprehensive specialized and Mekelle general hospitals, Mekelle, Tigray, Ethiopia. PLoS One. 2019;21;14(11): e0225536.
Hassan HE, Azzam H, Othman M, Hassan M, Selim T. Soluble E-selectin, platelet count and mean platelet volume as biomarkers for preeclampsia. Pregnancy Hypertens. 2019;17:1-4.
DOI: 10.1016/j.pregnhy.2019.04.008.Epub 2019 Apr 26.
Artunc Ulkumen B, Pala HG, Calik E, Oruc Koltan S. Can mean platelet volume and platelet distribution width be possible markers for ectopic pregnancy and tubal rupture? (MPV and PDW in ectopic pregnancy). Pak J Med Sci. 2014; 30(2):352-5.
Karateke A, Kurt RK, Baloglu A. Relation of platelet distribution width (PDW) and platelet crit (PCT) to preeclampsia. Ginekol Pol. 2015;86(5):372-5.
Artunc Ulkumen B, Pala HG, Calik E, Oruc Koltan S. Platelet distribution width (PDW): A putative marker for threatened preterm labor. Pak J Med Sci. 2014;30(4):745-8.
Yücel B, Ustun B. Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume, red cell distribution width and plateletcrit in preeclampsia. Pregnancy Hypertens. 2017;7:29-32.
DOI: 10.1016/j.preghy.2016.12.002. Epub 2016 Dec 23.
Sitotaw C, Asrie F, Melku M. Evaluation of platelet and white cells parameters among pregnant women with preeclampsia in Gondar, Northwest Ethiopia: a comparative cross-sectional study. Pregnancy Hypertens. 2018;13:242-247.
DOI: 10.1016/j.preghy.2018.06.006. Epub 2018 Jun 9.
Gogoi P, Sinha P, Gupta B, Firmal P, Rajaram S. Neutrophil-to-lymphocyte ratio and platelet indices in preeclampsia. Int J Gynaecol Obstet. 2019;144(1):16-20.
DOI: 10.1002/ijgo.12701. Epub 2018 Nov 11.
Siristatidis C, Christoforaki V, Zafeiriou Z, Mastorakos G, Vrantza T, Daskalakis G. First trimester neutrophil-to-lymphocyte ratio (NLR) and pregnancy outcomes in medically assisted reproduction (MAR): a case control study. Gynecol Endocrinol. 2019;35(5):434-438.
Epub 2019 Jan 6.
Hershko Klement A, Hadi E, Asali A. Neutrophils to lymphocyte ratio and platelets to lymphocyte ratio in pregnancy: A population study. PLoS One. 2018;13(5): e0196706.
Abstract View: 396 times
PDF Download: 125 times