Diagnostic Value of Serum Leptin Level in Critically Ill Septic Child
Asmaa A. Abo El Yazeed *
Basioun Central Hospital, Ministry of Health, Egypt.
Ahmed I. Harkan
Pediatrics Department, Faculty of Medicine, Tanta University, Egypt
Amira Y. Ahmed
Clinical Pathology Department, Faculty of Medicine, Tanta University, Egypt.
Ahmed A. Abo Elezz
Pediatrics Department, Faculty of Medicine, Tanta University, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Diagnosis of sepsis is important to reduce morbidity and mortality. Leptin is an important immunoregulatory hormone that enhances a number of immune responses in sepsis.
Objective: to assess serum leptin in diagnosing sepsis in critically ill pediatric patients.
Subjects and Methods: This study was carried out on 50 children divided into a case group included 40 critically ill patients initially sepsis free and fulfilling 2 of 4 criteria of SIRS admitted to the Pediatric Intensive Care Unit, children hospital, Tanta university and a control group included 10 apparently healthy children. According to the presence or absence of infection, our patients were classified into SIRS group and sepsis group. For all studied patients; serum leptin, CRP and others indicators of sepsis were measured at admission and 72h later, while were measured one time only for control group.
Results: patients who developed sepsis had significantly higher serum leptin levels than those of the control group and SIRS (33.9 ± 20.8 vs. 1.9 ± 0.4, 21.5+ 10.1 respectively, p>0.05).
Conclusion: Serum leptin may have a role in early diagnosis of sepsis.
Keywords: Diagnostic value, serum leptin, critically Ill, septic child