Association between N-terminal Pro-Brain Natriuretic Peptide and Acute Ischemic Stroke in Male Patients
Syeda Aleya Sultana
Department of Cardiology, Combined Military Hospital, Dhaka, Bangladesh.
Muhammad Rezeul Huq
*
Department of Neurology, Combined Military Hospital, Dhaka, Bangladesh.
Mohammad Abdul Malek
Department of Cardiology, Combined Military Hospital, Dhaka, Bangladesh.
Ghulam Kawnayn
Department of Neurology, Combined Military Hospital, Dhaka, Bangladesh.
Rezwana Siddique
Department of Cardiology, Combined Military Hospital, Dhaka, Bangladesh.
Md Ziaul Haque
Department of Neurology, Combined Military Hospital, Dhaka, Bangladesh.
Dewan Mohaimenul Haque
Department of Neurology, Combined Military Hospital, Dhaka, Bangladesh.
Nusrat Zahan Mila
Department of Neurology, Combined Military Hospital, Dhaka, Bangladesh.
Nurani Hanfa
Department of Cardiology, Combined Military Hospital, Dhaka, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
Aims: Stroke is among the major cause of mortality and disability globally. Many types of research are ongoing in search of a reliable biomarker for acute ischemic stroke. This study was aimed to see the association of the serum N-terminal proBNP (pro-brain natriuretic peptide) or NT-proBNP with acute ischemic stroke.
Study Design: Case-control study.
Methodology: This case-control study was conducted from January 2023 to June 2023. A total of 30 acute ischemic stroke male patients were enrolled as cases with 30 healthy male controls. Serum NT-proBNP level was measured in all the participants. Clinical features including the National Institute of Health Stroke (NIHSS) scale score were recorded in cases.
Results: The mean ages of the cases and controls were 61 ± 9.22 and 62.40 ± 8.23 years respectively. Among the acute ischemic stroke patients, more than half of the patients (53%) had lacunar stroke. According to the NIHSS score, more than 90% of the patients had minor or moderate stroke (93.3%). The mean NT-proBNP of cases was significantly higher than the controls (266.99 ± 357.88 vs 46.32 ± 18.59) (P = .04). The mean logNT-proBNP level (1.96 ± 0.72) was also significantly higher among the cases than the controls (1.61 ± 0.22) (P = .04). We did not find any association of serum logNTpro-BNP with the duration of stroke (P = .40). There was also no statistically significant association between the NIHSS score and NT-proBNP or logNTpro-BNP levels (P = .36).
Conclusion: Serum NT-proBNP level was significantly higher in acute ischemic stroke patients. There was no association of NT-proBNP level with the stroke severity and duration.
Keywords: Ischemic stroke, NT-proBNP, biomarker, stroke severity