Journal of Advances in Medicine and Medical Research

Background: Obesity became an important health problem in last years. It’s relation with many inflammatory markers and indexes were studied.

Aim: The present study aimed to analyze the role of Systemic Immune Inflammation Index (SII) and Systemic Inflammatory Response Index (SIRI) in bariatric surgery.

Materials and Methods: Single-center, observational, cross-sectional, and retrospective study was carried out. Data about demographics, comorbidities, excess weight loss (EWL), as well as body mass index (BMI) , laboratory results, and inflammatory markers including platelet lymphocyte ratio (PLR), neutrophil lymphocyte ratio (NLR), monocyte lymphocyte ratio (MLR) were recorded preoperatively and postoperatively at 1^st, 6^th, 12^th and 24^th months. The SII and SIRI values also calculated preoperatively and at 1^st, 6^th, 12^th and 24^th months after surgery.

Results :A total of 149 patients operated on by a single surgeon were studied. The mean age of the patients was 36.77±11.39 (18-66). When we compare the preoperative and postoperative values of SII and SIRI, all values were decreased after bariatric surgery.

Conclusions: Inflammatory indexes, SII and SIRI were decreased after bariatric surgery. Although there was a weak correlation between EWL and SIRI only at the postoperative 24 months, there was no clear relationship in between EWL and SII/SIRI in all other time periods.