Journal of Advances in Medicine and Medical Research

Background: Chronic ischaemic heart disease can be accompanied by hepatic structural injury, but age-stratified histopathological descriptions in young patients remain limited.

Aims: To determine the pathomorphological aspects of liver structural changes in young patients with chronic ischaemic heart disease.

Methods: A descriptive, autopsy-based histopathological study examined liver tissue from 38 patients aged 25–44 years. Patients were divided into four age groups: 25–30 years (n=8), 31–35 years (n=8), 36–40 years (n=9), and 41–44 years (n=13). Anamnestic, macroscopic, and microscopic examinations were performed, and histological sections were stained with haematoxylin-eosin and by the Van Gieson method.

Results: In the 25–30-year group, dystrophic hepatocyte changes, moderate expansion of the space of Disse, and largely preserved lobular architecture were observed. In the 31–35-year group, cytoplasmic clarification and karyopyknosis were more evident, with disruption of the radial-beam structure and perisinusoidal swelling. In the 36–40-year group, hydropic dystrophy, karyorrhexis, karyolysis, and greater architectural disruption were present. In the 41–44-year group, focal hepatocyte necrosis, marked expansion of the space of Disse, and disrupted lobular structure were observed.

Conclusion: The findings show a descriptive gradient of dystrophic, necrobiotic, and necrotic liver changes across the four age groups, with more pronounced structural injury in the older groups. Interpretation should remain limited to the histopathological evidence obtained in this study.