Journal of Advances in Medicine and Medical Research <p style="text-align: justify;"><strong>Journal of Advances in Medicine and Medical Research (ISSN:&nbsp;2456-8899)</strong> aims to publish research papers, reviews and short communications in the areas of medicine and medical research.&nbsp; JAMMR will not only publish traditional full research reports, including short communications, but also this journal will publish reports/articles on all stages of the research process like study protocols, pilot studies and pre-protocols. JAMMR is novelty attracting, open minded, peer-reviewed medical periodical, designed to serve as a perfectly new platform for both mainstream and new ground shaking works as long as they are technically correct and scientifically motivated.&nbsp;The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> en-US (Journal of Advances in Medicine and Medical Research) (Journal of Advances in Medicine and Medical Research) Fri, 20 Nov 2020 11:42:59 +0000 OJS 60 Accuracy of Combined Measure of Serum Uric Acid and Beta Human Chorionic Gonadotropin (β hCG) Versus Serum Beta Human Chorionic Gonadotropin Alone as Prognostic Indicators of Pregnancy Outcome of Preeclampsia <p><strong>Background:</strong> Measurement of variety of biological, biochemical and biophysical markers in pregnancy implicated in the pathophysiology of preeclampsia have been proposed to predict its development.</p> <p><strong>Aim:</strong> To evaluate the accuracy of combined measure of maternal serum uric acid level and quantitative serum beta hCG versus serum beta hCG alone as prognostic indicators of pregnancy outcome among preeclamptic patients at the Federal Medical Centre, Yenagoa.</p> <p><strong>Methods:</strong> This is a hospital based prospective case control study by systematic sampling selection. The two groups comprised of 100 consecutive patients each, one with pre-eclampsia (study group) and the other without pre-eclampsia (control) admitted for management into the antenatal ward and labour ward over the seven-month period of the study. The values of their serum uric acid and beta hCG levels were evaluated on admission and followed up. Data entry and statistical analysis was done using statistical package for social science (windows version 22.0. SPSS Inc; Chicago, USA). Level of significance was set at P &lt; 0.05.</p> <p><strong>Results: </strong>The mean quantitative serum β hCG level amongst the subjects (26776.6 ± 19590.5) was statistically significantly higher (p &lt; 0.001) than the mean quantitative serum β hCG level amongst the control (7973.6 ± 4193.7). The prognostic accuracy in predicting pregnancy outcomes were: HELLP syndrome (0.33, 0.44), Eclampsia (0.50, 0.39), Acute Renal Failure (0.44, 0.33), IUGR (0.43, 0.39), IUFD (0.38, 0.27) and Birth Asphyxia (0.49, 0.38) respectively for combined measure of serum uric acid and serum β hCG, and serum β hCG alone.</p> <p><strong>Conclusion: </strong>Serum β hCG levels remains a useful prognostic indicator for feto-maternal outcome in preeclamptic women. However, combined measure of serum uric acid and serum β hCG level in prognosticating pregnancy outcome in preeclamptic women was shown to have a better accuracy than serum β hCG.&nbsp;&nbsp;</p> E. O. S. Aigere, D. O. Allagoa, E. L. Kotingo, L. Obagah, B. E. Kasia, P. C. Oriji ##submission.copyrightStatement## Fri, 20 Nov 2020 00:00:00 +0000 Evaluation of Dento-craniofacial Characteristics in Monozygotic Twins - Case Study <p><strong>Introduction:</strong> Monozygotic twins are a valuable sample for the study of human craniofacial growth and development.</p> <p><strong>Aims:</strong> The aim of the present study was to analyze the dento-craniofacial characteristics in monozygotic twins and to discuss the genetic, epigenetic and environmental influences in the twin’s phenotypic features.</p> <p><strong>Material and Methods:</strong> Two 21-year-old female twins attended the Dental Service of Universidade Federal dos Vales do Jequitinhonha e Mucuri were analyzed. For validation of this study, a genetic test of zygosity was performed to confirm the individuals' monozygosity. Intraoral buccal examination revealed occlusal differences as well as disagreement in the eruption of the third molars.</p> <p><strong>Results:</strong> The analysis of models showed differences in the mesio-distal diameter of the teeth of both arches, as well as disagreement in the perimeter of the mandibular arches between the two individuals. The cephalometric analysis showed remarkable differences in the vertical and horizontal parameters of the craniofacial structure. The SNA, SNB and LAFH showed differences of 10º, 9º and 3mm respectively. Additionally, the components related to the dentition also showed discrepant results.</p> <p><strong>Conclusion:</strong> It can be suggested that the dento-craniofacial characteristics present a genetic component; however, the interaction of epigenetic and environmental factors can lead to different phenotypes in univiteline twins.</p> Gabriela Rocha- Gomes, Noádia Abreu Souza, Fernanda Rocha- Gomes, Bruna de Cássia Ávila, Rejane Pereira Otoni, Saulo Gabriel Moreira Falci, Thiago Fonseca- Silva ##submission.copyrightStatement## Sat, 21 Nov 2020 00:00:00 +0000 Plasma Growth Differentiation Factor-15 as a Prognostic Biomarker in Children with Congestive Heart Failure <p><strong>Aim and Objectives: </strong>This study aimed to evaluate the plasma levels of Growth Differentiation Factor-15 (GDF-15) in children with congestive heart failure, also to evaluate the diagnostic and prognostic value of this novel biomarker in pediatric congestive heart failure, by correlation of its levels with the clinical status and the echocardiographic data of these patients.</p> <p><strong>Subjects and Methods:</strong> This study was conducted on Thirty (30) children with congestive heart failure (CHF), Patients were selected from those admitted to Pediatric Cardiology Unit, Pediatric Department, Tanta University Hospital, from (August 2018-April 2020), and thirty (30) healthy children, matched for age and sex, were enrolled as a control group. All children in this study were subjected to Plain X-ray chest and heart: Cardiothoracic ratio (CTR) was measured, and Echocardiographic assessment: Doppler and Two-dimensional, M-mode Echocardiographic evaluation of these parameters and Plasma level of Growth Differentiation Factor-15 (GDF-15) was measured. &nbsp;</p> <p><strong>Results: </strong>the results revealed that The best cutoff point of GDF-15 to differentiate between cases with CHF and control group was &gt;446.5 ng/l with 93.33% sensitivity, 90% specificity, 90.3% PPV, 93.1% NPV and AUC was 0.992.</p> <p>There was significant decrease of EF% and FS% (systolic dysfunction of LV) in patients with CHF as compared to control group.</p> <p>There was statistically significant positive correlation between plasma level of GDF-15 and Ross clinical stage of CHF.</p> <p>There was statistically significant negative correlation between GDF-15 and EF%, FS % by echocardiography.</p> <p><strong>Conclusion:</strong> Plasma levels of GDF-15 were elevated in children with CHF, and these levels were correlated to the Ross staging of CHF and echocardiographic assessment of LV function. Plasma levels of GDF-15 were elevated in patients with bad prognosis, denoting its prognostic value as a novel biomarker in pediatric CHF.</p> Abrar Mohamed Khayal, Shimaa Basyoni El- Nemr, Hesham Ahmed El- Serogy, Amr Mohamed Zoair ##submission.copyrightStatement## Mon, 23 Nov 2020 00:00:00 +0000 Potential Impact of Nutrition on Immune System: Prevent or Assist COVID-19 Recovery <p>In human beings, infection risk and severity differ according to immune competence based on how the immune system grows, matures, and declines. Many factors affect the immune system and its competencies, including diet. A number of clinical trials are underway to determine treatment options for coronavirus disease 2019 (COVID-19), caused by extreme acute coronavirus syndrome. Considering Covid-19, enhanced nutrition including micronutrient supplementation to improve the immune system has been recognized as a viable solution to both preventing and alleviating infection severity. Micronutrient deficiencies, especially vitamins A, B complex, C, and D including trace minerals zinc, iron, and selenium, are prevalent among vulnerable populations in general, and among COVID-19 patients in particular, and may likely increase mortality risk. A systematic review of the literature was conducted to identify nutritional strategies that might prevent or assist COVID-19 recovery. There is still an unmet need for covering the treatment of geriatric and pediatric patients.</p> Sudhanshu Mishra, Disha Sharma, Anshita Raghuvanshi, Aishwarya Rajput, Vikash Chaturvedi, Kumari Shanno ##submission.copyrightStatement## Mon, 23 Nov 2020 00:00:00 +0000