Open Access Case Report

Uterine Leiomyosarcoma: A Case Report and Review of Relevant Literatures

A. J. Omotoso, P. O. Odusolu, M. A. Nnoli, E. L. Ekpe, K. Omoruyi

Journal of Advances in Medicine and Medical Research, Page 1-4
DOI: 10.9734/jammr/2019/v29i530088

Leiomyomas are benign soft tissue neoplasms that arise from smooth muscles. Leiomyosarcoma is a malignant lesion of smooth muscle origin. This is a rare lesion in the uterus with 1-2 % of its benign counterpart, leiomyoma, transforming into the lesion. It is often aggressive and could develop at any site where the smooth muscle is found.  We present a case of a 48-year-old farmer with pelvic mass with Ultra-sonography(USS) suggestive of leiomyoma. Hysterectomy was done and histologic diagnosis of leiomyosarcoma (LMS) was made. The patient was discharged 7 days post operation but was lost to follow up. Uterine LMS is an aggressive tumour, therefore, a high index of suspicion is needed especially for huge uterine nodules and such patients must be closely monitored for adequate management.

Open Access Case Study

Transarterial Embolization for Renal Hemorrhage after Percutaneous Nephrolithotomy

Mohammed Habib, Mohammed Hillis, Majed Shunnat, Mohammed Matar

Journal of Advances in Medicine and Medical Research, Page 1-4
DOI: 10.9734/jammr/2019/v29i530091

Percutaneous nephrolithotripsy (PNL) is a safe and effective treatment modality for the management of renal stones. This technique is associated with high success rates and few complications. The most important complication is hemorrhage. Delayed hemorrhage following PNL is rare complication and usually occurs due to development of the pseudoaneurysm or Arteriovenous fistula which can be successfully managed with arterial embolization. Here we are reporting a case of delayed post-PNL bleeding that occurred in a 41-year-old male operated on for renal stone. Multi Detector Computed Tomography scan revealed a presence of the pseudoaneurysm and Arteriovenous fistula in the inferior segmental branch of the left renal artery, which was successfully managed with amplatzer vascular plug.

Open Access Short Communication

An Insight about the Referral System in Health Care Network: Flaws with Recommendations for Improvement

M. Bilal, A. Umar, S. M. Raza

Journal of Advances in Medicine and Medical Research, Page 1-8
DOI: 10.9734/jammr/2019/v29i530086

Healthcare network is composed of primary, secondary and tertiary care centers. Purpose of each unit in this sophisticated zone is to allow steady and smooth delivery of healthcare to optimum level without wasting essential resources or time. If, primary care centers are not able to fulfill the needs of any health issues then, patients are referred to more advanced setup where their health issues can be timely addressed in a proficient way. Referral system forms an important component of healthcare network and it should be formulated in such a way that it can bring fruitful results with the proper use of time, energy, man force as well as technical resources without compromising patient’s health. In this paper, we discussed the core of healthcare network in the city, working with primary as well as referral health care centers, flaws affecting the referral system and recommendations to improve them.

Open Access Original Research Article

Comparative Study on Color Stability of Denture Reline Polymers when Using Microwave and Chemical Disinfection

Farhat Jabeen, Rajeev Gupta, Archana Nagpal, Vishal Katna, Vishwas Mahajan, Pragya Bali

Journal of Advances in Medicine and Medical Research, Page 1-7
DOI: 10.9734/jammr/2019/v29i530085

This study investigated the color stability of reline resin after two methods of disinfection i.e  microwave disinfection and chemical disinfection. A stainless steel mold with a breakaway compartment (10 mm in diameter by 0.7 mm thickness) was made to fabricate specimens of various resins. Each material was mixed according to manufacturer’s instructions and applied into the mold. Prior to color stability testing, specimens were cleaned in distilled water for 20 minutes to kill any microorganisms that may had contaminated the discs during fabrication. And then specimens were immersed in Sodium Perborate Monohydrate 200 ml of solution for 15 days and microwaved for 15 days so that it is comparable to chemical disinfection soaking. The color stability of each specimen was measured again using spectrophotometer and values were obtained. The data of ∆E, ∆L, ∆b, ∆a were analysed by 2 way repeated measures ANOVAs test. Significant statistic changes in color parameters ∆L, ∆a, ∆b of the reline resin DPI, Ufi Gel Hard And Kooliner were observed when dentures were disinfected by Sodium Perborate Monohydrate 2% solutions. The color stability of the reline resin was influenced by time, regardless of disinfection or non disinfection. This can be attributed to bleaching (whitening) effect of reline material. Discoloration of resin based materials may be caused by intrinsic or extrinsic factors. Intrinsic factors are related to internal alterations in material resulting from physicochemical reactions or residual monomer oxidation with time. Thus the initiator, quantity and type of monomer and the polymerisation efficiency can affect the color stability of resin based materials. The color stability deviation value ∆E significantly increased to maximum for chemical disinfectant, least for Control group and intermediate for microwaved group. Ufi Gel showed the highest deviation ∆E and Control Group showed the lowest deviation according to results.

Open Access Original Research Article

Estimation of Serum Lipid Profile and Its Correlation with Alveolar Bone Height in Chronic Periodontitis

Avadhut Kamble, Mukta Motwani, Naman Shah

Journal of Advances in Medicine and Medical Research, Page 1-6
DOI: 10.9734/jammr/2019/v29i530087

Aim: Numerous studies have been previously carried out to find out any correlation between lipid profile and periodontitis but existence of an association does not establish whether periodontitis causes an elevation in serum lipid level or elevation in serum lipid profile predispose to periodontitis. The aim of the present study was to find any significant correlation between HDL, LDL, VLDL and cholesterol with periodontitis.

Material and Methods: 100 patients with chronic periodontitis (group I) and 50 healthy patients (group II) were selected. The levels of serum lipid, including HDL, LDL, VLDL, and TOTAL CHOLESTEROL along with fasting blood glucose were assessed. The relationship between severity of periodontitis based on clinical and radiographic finding with serum lipid correlated. Results: There was no significant difference found between mean values of total cholesterol, LDL and VLDL among study and control group. Only HDL showed a highly significant difference (p< 0.00) between healthy and patient with chronic periodontitis.

Conclusion: Estimation of serum lipid profile, especially HDL levels in subjects with periodontitis can be considered as a screening method for early diagnosis of atherosclerosis to avoid further progression of cardiovascular changes in early age of the life.

Open Access Original Research Article

Histological Changes of Spleen Autotransplanted in the Omentum of Rats

Mohammad Reza Javadi, Ali Reza Monsef Esfahani, Nazila Hassanzadeh Ghavifekr, Amin Niayesh

Journal of Advances in Medicine and Medical Research, Page 1-7
DOI: 10.9734/jammr/2019/v29i530089

Introduction: The spleen is a lymphoid organ that plays an important role in the body's defense against organisms, participation in blood filtration process, phagocytosis and immunoglobulin production. When splenectomy due to severe splenic trauma or hematological disorder is inevitable, spleen autotransplantation may be the only option to preserve the spleen. It has not been determined the structural rearrangements after transplanting in comparison with the amount of transplanted spleen. The aim of this study was to evaluate the histological changes of spleen autotransplanted in the omentum of rats.

Materials and Methods: In this experimental study, 16 male Wistar rats underwent splenectomy and transplanting three pieces of splenic tissue consists of 10-15% of the greater omentum. The rats were divided to two equal groups; Eight caseswere randomly separated and followedfor 6 months (Group Au-6) and 8 other cases also were separated for 12 months' follow-up (group Au-12). At the end of follow-up period, after the re-operation of autotransplanted rats, the splenic tissues underwent the macroscopic and microscopic examination and two groups were compared together.

Results: After laparotomy, splenic tissues were detected in all cases (8/8, 100%) of Au-6 group and 7 cases (87.5%) of Au-12 group. It’s observed no significant difference between two groups in the capsule around splenic tissue, organized structure, fibrosis and revascularization (P>0.05). The hemosiderin pigmentation was significantly higher in Au-12 group (P=0.03).

Conclusions: The results of this study showed that autotransplanting about 15 percent of splenic tissue were associated with a high success rate in tissue structure rearrangement. Therefore, spleen autotransplantation even in small sizes was highly recommended in cases of unavoidable splenectomy.

Open Access Original Research Article

Phytochemical and Antimicrobial Study on the Leaf Extract of Tapinanthus dodoneifolius (Van Teigh) Loranthaceae

M. Mohammed, A. Y. Idris, I. Gandu, U. M. Tanko, A. Muhammad, A. A.Adeiza

Journal of Advances in Medicine and Medical Research, Page 1-9
DOI: 10.9734/jammr/2019/v29i530090

Leaves of Tapinanthus dodoneifolius is used as traditional medicine for the treatment of menstrual   pain, wound, gonorrhea, and control of diarrhea and dysentery which was extracted by cold maceration in methanol. The concentrated methanol extract was subsequently partitioned with petroleum ether, chloroform, ethylacetate and n-butanol. Agar well Diffusion method was used to determine the antimicrobial activities of the extracts against Staphylococcus aureaus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Klebsiela pneumonia, Salmmnella typhi, Streptococcus pyogenes, Candida krusei, Candida tropicalis, and Candida albican at different concentrations. Antimicrobial sensitivity test indicated that, the extract inhibited the growth of all microorganisms to varying degrees except Pseudomonas aeruginosa and Candida krusei respectively. The in vitro   antimicrobial screening revealed that, the extracts exhibited diverse activities against different microbe’s concentrations ranging from 2.5mg/ml-5mg/ml. The plant extract was found to contain flavonoids, terpenoids, saponins, tannins and cardiac glycosides which may be responsible for its antimicrobial properties. The result justifies the traditional use of the plant leaf in the treatment of menstrual   pain, sexual transmitted diseases, wounds and control of dysentery and diarrhea.

Open Access Original Research Article

Synergistic Effect of Aqueous Extracts of Croton Zabensicus and Vernonia amygdalina Leaves as an Antihyperglycemic Agent in an Alloxan Induced Diabetic Albino Rats

I. A. Hassan, I. Abdulraheem, H. O. Emun, D. M. lawal

Journal of Advances in Medicine and Medical Research, Page 1-6
DOI: 10.9734/jammr/2019/v29i530092

Aims: This study was aimed at investigating the antihyperglycemic effect of a combined extract of Vernonia amygdalina and croton zabensicus compare with a hypoglycemic drug, glibenclamide.

Methodology: Twenty 20 experimental animals were used (albino rats); the rats were divided equally into four groups of five rats each; namely A (control), B (glibenclamide 10 mg/kg body weight), C (synergetic treatment 1000 mg/kg body weight), D (synergetic treatment 500 mg/kg of body weight). Diabetes was induced intraperitoneal using Alloxan Monohydrate to all the animals and their blood glucose rise above 200 mg/dl.

Results: It was observed that group B and group C treated with glibenclamide (10 mg/kg body weight) and synergetic aqueous extract (1000 mg/kg body weight) show significant decrease in the blood glucose level from 451.75 mg/dl to 64.50 mg/dl and 339.50 mg/dl to 182.50 mg/dl respectively compared with group D with 278.25 mg/dl to 194.75 mg/dl. However, a change was also observed in the body weight of the groups; Group A (Normal control) showed a continuous increase in the body weight, Group B, C and D were observed to have decreased in body weight from induction period, but a steady increase was observed as treatment commences.

Conclusion: Hence this combined extract can be used as antihyperglycemic; only that it is slower in remediation compared with the glibenclamide; but without side effect, as may be in the case of most standard drug.